Abstract:

Twenty-six chiral phosphorus compounds have been synthesized from L-aminoacids,D-camphor, (-)-ψ-ephedrine, (-)-α-phenylethylamine, and (S)-(-)-binaphthol as optical active source. Their catalytic activities in the asymmetric borane reduction of prochiral ketone and imine, the asymmetric alkylation of aldehyde with Et₂Zn,and the asymmetric silylcyanation of aldehyde were investigated. Among them, it was found that some compounds possess good catalytic activities.

Key words: Chirai phosphorus reagents, Ligand catalyst, Asymmetric borane reduction, Asymmetric alkylation, Asymmetric silylcyanation