Studies on NaOH-Catalyzed Conjugate Addition of Acetophenone with Chalcones under Solvent-Free Condition:Preparation of 1,5-Diketones

Abstract

Abstract:

The paper has reported that commerical NaOH efficently catalyzes Michael reactions of chalcones (1) with acetophenone (2) under solvent-free conditions. And a series of 1,5-di aryldiketones can be obtained in 71-90% yields. All the product structures were characterized satisfactorily by IR.¹HNMR.MS spectroscopy and elemental analysis. The procedure is performed by grinding the components with an agate mortar and a pestile under solvent-free at room temperature or preheating at 45℃ less than 1.3 hours. The result indicated that the aromatic systems are more active than the ferrocenyl analogous.

Key words: Under solvent-free, Acetophenone, Chalcones, 1,5-Diaryldiketones

CLC Number:

O626.26

TrendMD:

LIU Wan-Yi, LI Jin-Fu, MA Yong-Xiang, LIANG Yong-Min. Studies on NaOH-Catalyzed Conjugate Addition of Acetophenone with Chalcones under Solvent-Free Condition:Preparation of 1,5-Diketones[J]. Chem. J. Chinese Universities, 2001, 22(S1): 141.

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Studies on NaOH-Catalyzed Conjugate Addition of Acetophenone with Chalcones under Solvent-Free Condition:Preparation of 1,5-Diketones

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