Studies on the Synthesis and Characters of Ferrocene Labeled DNA Probe

Abstract

Abstract: The preparation and characters of a ferrocene labeled DNAprobe was studied. Ferrocene was labeled onto a denatured calf thymus DNAby EDC. The electrochemical character, UVspectrum and IRspectrum of the ferrocene labeled probe were discussed. It was suggested that the ferrocene be labeled on the phosphoric group of calf thymus DNA. The probe synthesis was simple, quick and of efficiency. It made bases for the application of electrochemical DNAprobe to DNAdetection, damage and protection.

Key words: Ferrocene, Label reaction, DNA electrochemical probe

CLC Number:

O657

TrendMD:

XU Chun, CAI Hong, HE Pin-Gang, FANG Yu-Zhi . Studies on the Synthesis and Characters of Ferrocene Labeled DNA Probe[J]. Chem. J. Chinese Universities, 2001, 22(9): 1492.

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Studies on the Synthesis and Characters of Ferrocene Labeled DNA Probe

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