Chem. J. Chinese Universities ›› 2001, Vol. 22 ›› Issue (8): 1352.

• Articles • Previous Articles     Next Articles

A Novel Synthetic Method of Hydratropic Aldehyde

SHI Zhen, LU Lin-Gang, WANG Yun-Xia   

  1. Department of Chemistry, Northwest University, Xi'an 710069, China
  • Received:2000-05-27 Online:2001-08-24 Published:2001-08-24

Abstract: Based on the one carbon unit transfer reaction of tetrahydrofolate coenzymes, hydratropic aldehyde was synthesized successfully by using benzimidazolium salt as tetrahydrofolate coenzyme model at formic acid oxidation level and Grignard reagent as a nucleophile to which one carbon unit was transfered. Anovel method for the preparation of hydratropic aldehyde was provided. The mechanism for the addition-hydrolysis reaction of benzimidazolium salt with Grignard reagent and the effects of reaction condition on the yield are discussed.

Key words: Hydratropic aldehyde, Benzimidazolium salt, Grignard reagent, Organic syntheses

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