Abstract: The electrochemical quartz crystal microbalance(EQCM) was used to study the electrochemical behavior of guanine, guanosine and guanosine phosphate on the gold electrode. The results show that the three biological molecules can be oxidized at 1.1 V, which might be caused by the oxidation of C-N bond within three studied molecules. According to the change of electric quantity and mass quantity, we have calculated the number of transferred electron, which is 4. The order of oxidation current is estimated as guanosine phosphate>guanosine>guanine, which might be caused by the different adsorption ability of those molecules.

Key words: Electrochemical quartz crystal microbalance(EQCM), Cyclic voltammograms, Guanine, Guanosine, Guanosine phosphate