Abstract: In a 0.1 mol/L NH₃ NH₄Cl buffer solution(pH9.50), a sensitive reduction peak of mitoxantrone at a Ni/GC modified electrode was obtained by linear-sweep voltammetry. The peak potential was -0.85 V( vs. SCE). The peak current was proportional to the concentration of mitoxantrone. The detection limit was 18×10^-8 mol/L. Its voltammetric behavior was studied and the wave was applied to the determination of mitoxantrone in urine. The reduction process was quasi-reversible with adsorption and catalysis. AES and XPS experiments showed that Ni was surely implanted into the surface of the GCE, and the implanted Ni at the GCimproved the electrocatalytic activity.

Key words: Ion implanted modified electrode, Voltammetric behavior, Mitoxantrone