Investigation of Retention and Chiral Recognition Mechanism of the Derivative β-Cyclodextrin Bonded Stationary Phase(Ⅱ)

Abstract

Abstract: The phenyl carbamate derivative β-cyclodextrin bonded phase CSP₁ and CSP₂ were prepared by the reaction of phenyl isocyanate. In normal phase condition, the enantiomers of a series of α-aminophosphonates have been separated on CSP₁ and CSP₂ by HPLC. In order to compare the different chromatographic property between the two CSPs, four molecular describing parameters reflecting the properties of the solutes were chosen to correlate against the experimental logarithim value of the capacity factor to form the quantitative structure enantioselective retention relationships(QSERRs) by the multivariable regression analysis and the factor analysis method. Through the QSERRs, the retention and enantioselectivity mechanism were examined.

Key words: HPLC, Cyclodextrin bonded phase, &alpha, Aminophosphonate, Chiral recognition mechanism, Quantitative structure enantioselective retention relationship

CLC Number:

O627

TrendMD:

HUANG Jun-Min, CHEN Hui, GAO Ru-Yu, WANG Qin-Sun . Investigation of Retention and Chiral Recognition Mechanism of the Derivative β-Cyclodextrin Bonded Stationary Phase(Ⅱ)[J]. Chem. J. Chinese Universities, 2001, 22(11): 1837.

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Investigation of Retention and Chiral Recognition Mechanism of the Derivative β-Cyclodextrin Bonded Stationary Phase(Ⅱ)

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