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Chem. J. Chinese Universities ›› 2001, Vol. 22 ›› Issue (1): 67.

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Studies on Imitation of SOD by N-Dodecanoyl-glycylglycinato-cuprate(Ⅱ)

XIE Ying1, ZHOU Xuan1, WANG Jun-Bo2, LI Feng-Mei3, DENG Xi-Xian4   

  1. 1. School of Pharmaceutical Science, Peking University, Beijing 100083, China;
    2. School of Public Health, Peking University, Beijing 100083, China;
    3. Institute of Low Energy Nuclear Physics, Beijing Normal Univrsity, Beijing 100875, China;
    4. Department of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received:2000-01-21 Online:2001-01-24 Published:2001-01-24

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Abstract: Anew kind of analogues of SOD(N-dodecacyl-glycylglycinato)-cuprate(Ⅱ) [Cu(C12-Gly-Gly)] and di-[N-dodecacyl-glyglycinate-cuprate(Ⅱ)][Cu(C12-Gly-Gly)2] were prepared. Their SODlike activities were studied by using pulse radiolysis. It was found that the SODlike activity would be improved through adding long chain on Gly-Gly, and close to the natural SOD. The new complexes achieved to imitate SODas a whole.

Key words: Analogues of SOD, N-Dodecacyl-glycylglycinato-cuprate(Ⅱ), Pulse radiolysis

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