Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (S1): 53.
• Analytical Sciences • Previous Articles Next Articles
WU Yi-Nan, PAN Yuan-Jiang, CHEN Yao-Zu
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The financial support of the NSFC is gratefully acknowledged.
Abstract:
In our previous work, Reaction Mass Spectrometry (RMS) has been applied to determine the configuration of some enantiomers[1-4], by using some chiral organic compounds such as R, S-α-hydroxyphenylacetic acid, R, S-α-methoxyphenylacetic acid and R, S-phenylbutyric anhydride etc. as reaction reagents. As a continuation of this investigation, a pair of new asymmetric compounds (R)- and (S)-1, 1'-binaphthyl-2, 2'-diyl-methylphosphate (R, S-BNP ester) are used as stereoselective reagents. By comparison of the relative abundances of characteristic ions formed by reaction between the sample and the two enantiomers of the reagent, the configuration of the samples can be determined at the micromole level within a few minutes by reaction mass spectrometry.
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WU Yi-Nan, PAN Yuan-Jiang, CHEN Yao-Zu. A Pair of New Chiral Reagents for Determining the Configuration of Some Organic Compounds by Reaction Mass Spectrometry[J]. Chem. J. Chinese Universities, 2000, 21(S1): 53.
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