Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (S1): 512.

• Synthetic Sciences • Previous Articles     Next Articles

A Convenient Synthesis of 2,5 (1H,3H)-Tetrahydroquinazolinedione Using Lanthanum Chloride as the Catalyst

LU Jun1, LI Wuan-Hua2, BAI Yin-Juan1, Ma Huai-Rang1   

  1. 1. Department of Chemistry, Northwest University, Xi'an 710069;
    2. Chemical Engineering, Northwest University, Xi'an 710069
  • Online:2000-12-31 Published:2000-12-31
  • Supported by:

    Financially was supported by the science foundation of Northwest University (98NW07F).

Abstract:

In the past decade,4-aryl-3,4-dihydropyrimidine derivatives have exhibited important pharmacological properties, e.g. as the integral backbones of several calcium channel blockers, antihypertensive agents, alpha-1a-antagonists, and neuropeptide Y (NPY) antagonists[1]. Several lead compounds were developed that are equal in potency and duration of antihypertensive activity to classical and second-generation dihydropyridine drugs[2].

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