Abstract:

Etoposide and Teniposide are used clinically in the treatment of various cancers, but their low solubility in water and high toxicity have being stimulated people to synthesize new active analoges. 5-fluorouracil (5-Fu) has been shown to be active in the treatment of rectal cancer, colonic cancer and matadenoma for fourty years. Because of obvious first-pass metabolism and low lipophilicities, its activity of antitumor have been decreased. A number of experiments showed that the drug must permeate the member of cell and bring into effect of drug. Considering the synergy effect of drugs, we had synthesized four novel etoposide analoges.