Abstract:

A "fluorous synthesis" approach is outlined in which organic molecules are rendered solublity in fluorocarbon solvents by attachment of a suitable fluorocanbon group. Fluorocarbon sovlents are immisicible in organic solutions, and fluorous molecules partition out of an organic phanse and into a fluorous phase in a standard liquid-liquid extraction. Simple yet substantive separations of organic reaction mixtures are achieved without resorting to chromatography. This methed has been used in many fields, but seldom in oligosacchride synthesis.