Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (S1): 163.
• Chemistry in Life Sciences • Previous Articles Next Articles
MENG Ge, CHEN Fen-Er
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The discovery of the crystal structure of HIV-1 reverse transcriptase (RT) provides a new clear target for designing anti HIV drugs with less side effects. 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT)and its analogs are selective HIV-RT linhibitors. Chemists carried out extensive studies on the modification of HEPT and provided a lot of data on biological activity of its analogs. In this paper 35 HIV-1RT inhibitors were selected from literature[1] and investigated by CoMFA method[2] for QSAR study.
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MENG Ge, CHEN Fen-Er. Three Dimensional Quantitative Structure Activity Relationship of Hept Analogs as HIV-1 Reverse Transcriptase Inhibitors[J]. Chem. J. Chinese Universities, 2000, 21(S1): 163.
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http://www.cjcu.jlu.edu.cn/EN/Y2000/V21/IS1/163