Abstract:

Phenylpropanoid glycosides (PPGs) are substances extracted from Pedicularis. They have been largely studied for their interesting biological and pharmacological properties^[1-3], in particular, their double role in the protection of DNA:preventing the DNA bases from radical attack, and rapidly repairing damaged DNA^[4-6]. A series of kinetic measurements has been performed with different deoxynucleotide radicals. Two major remakes can be done from the experimental results:(1) the reactivity of PPGs seems to depend on the number of phenolic hydroxyl groups; (2) the reactivity depends upon the positions of these groups. These observations are in agreements with the experiments performed on tumour cells.