Syhthesis and Superoxide Dismutase Activity Studies of β-Cyclodextrin Derivatives Containing1,2- Benzisoselenazol-3(2H)-one

Abstract

Abstract: Two novelβ-cyclodextrin derivatives containing 1,2 benzisoselenazol-3(2H)-one have been synthesized by a convenient method in 60% and 55% yields, respectively, and characterized by elemental analysis, IRand ¹H NMR. The superoxide dismutase (SOD) activity of these modified β cyclodextrins has been determined by the method of autooxidation of pyrogallol at 298.15 Kin buffer solution(pH = 8.20). The results obtained indicate that these cyclodextrin derivatives possesses relatively high SODactivity up to 179~330 U/mg.

Key words: 1,2-Benzisoselenazol-3-(2H)-one, β-Cyclodextrin, Imitating enzyme, Superoxide dismutase enzyme

CLC Number:

O641.4

TrendMD:

LI Bin, LI Li, LIU Yu, ZHENG Hao, DUAN Zhi-Yong . Syhthesis and Superoxide Dismutase Activity Studies of β-Cyclodextrin Derivatives Containing1,2- Benzisoselenazol-3(2H)-one[J]. Chem. J. Chinese Universities, 2000, 21(8): 1234.

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Syhthesis and Superoxide Dismutase Activity Studies of β-Cyclodextrin Derivatives Containing1,2- Benzisoselenazol-3(2H)-one

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