Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (7): 1064.

• Articles • Previous Articles     Next Articles

Two New Methods for Synthesis of 4β-Amino-4-deoxypodophyllotoxin and 4β-Amino-4'-demethyl-4-deoxypodophyllotoxin

CHEN Shao-Yuan1, YU Yong-Ping2, YOU Jin-Zong2, CHEN Yao-Zu2,3   

  1. 1. Departmentof Biology;
    2. Departmentof Chemistry, Zhejiang University, Hangzhou 310027;
    3. State Key Laboratory of App lied Organic Chemistry, Lanzhou University, Lanzhou 730000, China
  • Received:1999-06-07 Online:2000-07-24 Published:2000-07-24

Abstract: Two new methods for synthesis of 4β-amino-4-deoxypodophyllotoxin and 4β-amino-4'-demethyl-4-deoxypodophyllotoxin have been developed. These compounds were synthesized by reduction of the corresponding4β-anzido-podophyllotoxin derivatives with SmI2 or HCO2NH4/Pd-Cin excellent yields under mild conditions with convenient manipulation.

Key words: Podophyllotoxin, Samarium diiodide, Ammonium formate

CLC Number: 

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