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Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (12): 1820.

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Structure Determination of a Novel Ether-linkaged Bisalkaloid Acutiaporberine

LIN Cui-Wu1, SU Jing-Yu2, ZENG Long-Mei2, LI Hong-PENG2, Wen-Lie3, XU An-Long3   

  1. 1. School of Chemistry and Chemical Engineering, Guangxi Univer sity, Nanning 530004, China;
    2. School of Chemistry and Chemical Engineering, Zhongshan University, Guang zhou 510275, China;
    3. School of Life Science, Zhong shan University, Guangz hou 510275, China
  • Received:1999-10-25 Online:2000-12-24 Published:2000-12-24

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Abstract: Anovel ether linkaged bisalkaloid, acutiaporberine(Ⅰ) , was isolated from the root of Thalictrum acutifolium (Hand.Mazz.) Boivin.Its structure was determined by IR, MS, 1H NMR, 13C NMR, and2D NMR( 1H1HCOSY, 13C1H COSY, NOESY, and HMBC).Ether linkaged bisalkaloids, such as aporphine benzylisoguinoline type and bisbenzylisoquinoline type, have been found.Herein a novel type bisalkaloid composed of an aporphine and a protobebertine is reported for the first time.Compound Ⅰ can inhibit the growth of tumor cells and apoptosis can be seen.However, compound Ⅰ shows only slight toxic effects on normal soma cell lines

Key words: Thalictrum acutifolium (Hand.Mazz.) Boivin, Ether linkaged bisalkaloid, Aporphine, Protobebertine, Acutiaporberine(Ⅰ)

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