Abstract: Research progress in synthetic peptide vaccine has been reviewed. Various methods seeking for epitopic peptides, including enzyme hydrolysis and chemical cleavage, deductive method aided by computer, chemically synthetic peptide method and X-ray crystal structure, were discussed. Preparation methods and applications of various synthetic peptide antigens such as peptide-carrier complex antigen, polymeric peptide antigen, etc, used in vaccination recently have been introduced systematically.

Key words: Peptide vaccine, Autigenic peptide, Adjuvant