Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis

Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (1): 66.

• Articles • Previous Articles Next Articles

Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis

WANG Shi-Long¹, WANG Mei¹, SUN Xiao-Yu¹, ZHANG Chao-Jie¹, MA Xiu-Wen¹, NI Ya-Ming¹, YAO Si-De², WANG Wen-Feng²

1. Analysis and Research Centre of Tongji University, Shanghai 200092, China;
2. Laboratory of Radiation Chemistry, Shanghai Instituteof Nuclear Research, Academia Sinica, Shanghai 201800, China

Received:1999-03-26 Online:2000-01-24 Published:2000-01-24

Abstract

Abstract: One-electron reduction potential is one of the important parameters of radiosensitive compound with a high electron affinity. In this work one-electron reduction potentials of podophyllotoxin and its derivatives were determined by pulse radiolysis using duroquinone as references. The one-electron reduction potentials of podophyllotoxin, 4'-demethylepipodophyllotoxin(DMEP) and etoposide (VP-16) are -310 mV, -339 mV, -334 mV, respectively.

Key words: Podophyllotoxin and its derivative, Pulse radiolysis, One-electron reduction potential

CLC Number:

R914.5

TrendMD:

WANG Shi-Long, WANG Mei, SUN Xiao-Yu, ZHANG Chao-Jie, MA Xiu-Wen, NI Ya-Ming, YAO Si-De, WANG Wen-Feng. Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis[J]. Chem. J. Chinese Universities, 2000, 21(1): 66.

[1]	ZHAO Wen-En, HUANG Jin-Yong, WANG Wen-Feng, QIAN Su-Ping, YAO Si-De. Reaction of Carotenoids with Nitrogen Dioxide Radical(NO^·₂) [J]. Chem. J. Chinese Universities, 2006, 27(3): 556.
[2]	WANG Shi-Long, WANG Mei, SUN Xiao-Yu, ZHANG Zhen, LI Min, NI Ya-Ming, YAO Si-De, WANG Wen-Feng. Analyses of the Transient Species of Podophyllotoxin and Its Derivatives [J]. Chem. J. Chinese Universities, 2003, 24(11): 2014.
[3]	ZHANG Fu-Gen, WU Ji-Lan, LI Feng-Mei, LIU An-Dong . Pulse Radiolysis Kinetic Studies of the Self Decay of α-Hydroxyl Ethyl Peroxyl Radicals and Their Reactions with Quercetin and Pyrocatechol [J]. Chem. J. Chinese Universities, 2002, 23(3): 461.
[4]	DONG Wen-Bo, WANG Shu-Hui, YAO Si-De, HOU Hui-Qi . Mechanism Studies on Reactions of ^·OH,^·H和e_a^-_q with 2-Chlorophenol in Aqueous Solutions [J]. Chem. J. Chinese Universities, 2002, 23(10): 1896.
[5]	XIE Ying, ZHOU Xuan, WANG Jun-Bo, LI Feng-Mei, DENG Xi-Xian . Studies on Imitation of SOD by N-Dodecanoyl-glycylglycinato-cuprate(Ⅱ) [J]. Chem. J. Chinese Universities, 2001, 22(1): 67.
[6]	CHU Gao-Sheng, YAO Si-De, CHEN Jia-Fu, ZHANG Zhi-Cheng, ZHANG Man-Wei. Study on Oxidation and Electron Transfer in Phosphoryldipeptide Methyl Ester [J]. Chem. J. Chinese Universities, 1998, 19(2): 305.
[7]	CHEN Jia-Fu, YAO Shi-De, CHU Gao-Sheng, ZHANG Zhi-Cheng, ZHANG Man-Wei, WANG Wen-Feng, LIN Nian-Yun. Series of Studies of Vitamin K by Pulse Radiolysis and Laser Photolysis(Ⅰ)─A Pulse Radiolysis Studies of the Reduction Reaction of VK₃ in Aqueous Solution [J]. Chem. J. Chinese Universities, 1997, 18(12): 2004.
[8]	Shen Meng-chang, Luo Qin-hui, Zhu Shou-rong, Tu Qing-yun, Dai An-bang, Liu An-dong, Gu Hong-chun, Li Feng-mei, Di Shao-jie. A Kinetic Study on Dismutation of Superoxide Ion by Macrocyclic Dioxotetramine-Copper(Ⅱ) Complex by Using Pulse Radiolysis [J]. Chem. J. Chinese Universities, 1990, 11(12): 1322.

Determination of One-electron Reduction Potentials of Podophyllotoxin and Its Derivatives by Pulse Radiolysis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 8

Recommended Articles

Metrics

Comments