Abstract:

The drug-abuse is one of the most serious social problems in the world today. Abused drugs can produce dependence and are often misused or overdosed. Some drugs are continuously causing severe poisoning and deaths. In these cases, a great variety of drugs are involved. Comprehensive drug screening is therefore needed. Suitable sample preparation is an important prerequisite for GC-MS detection of biosamples. The major disadvantage of liquid-liquid extraction (LLE) is emulsion formation,which leads to lower recoveries. And also LLE methods are tiresome and displayed problems of variable recoveries. Solid-phase extraction (SPE) has several advantages over LLE, it gives good recoveries, reproducibilities and speed.