Synthesis of Ruthenium Polypyridyl Complexes and the Steric Influence of the Intercalated Ligand on DNA-Binding

Abstract

Abstract: Two structurally related ligands dmtatp(2,3-dimethyl-1,4,8,9-tetraazatriphenylene), dptatap(2,3-diphenyl-1,4,8,9-tetraazatriphenylene) and their ruthenium(Ⅱ) complexes [Ru(bpy)₂dmtatp]²⁺(1) and [Ru(bpy)₂dptatp]²⁺(2) were synthesized and characterized. Combined with the previous study data of [Ru(bpy)₂tatp]²⁺(3, tatp=1,4,8,9-tetraazatriphenylene) the steric influence of the intercalated ligand of these complexes on DNA-binding were investigated by electronic absorption, steady state luminescence, CDspectra and viscosity measurement. All the data suggested that the complexes bind with DNA by intercalation and the order of binding affinities is 3>2>1, consistent with the reduced steric effect of the intercalated ligand.

Key words: Ruthenium(Ⅱ) polypyridyl, Calf thymus DNA, Intercalation, Steric effect

CLC Number:

O614.92

TrendMD:

ZHEN Qi-Xiong, YE Bao-Hui, LIU Jin-Gang, JI Liang-Nian, WANG Lei . Synthesis of Ruthenium Polypyridyl Complexes and the Steric Influence of the Intercalated Ligand on DNA-Binding[J]. Chem. J. Chinese Universities, 1999, 20(11): 1661.

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Synthesis of Ruthenium Polypyridyl Complexes and the Steric Influence of the Intercalated Ligand on DNA-Binding

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