Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 448.
• Physical Organic Chemistry • Previous Articles Next Articles
Zuo Yumin1, Xu Jie2, Ren Sumei2
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Abstract: Compactin(1) and lovastatin(2) are potent inhibitors of cholesterol biosynthesis in humans, and the more active semisynthetic derivative simvastatin(3) are pharmacologically useful compounds for lowering of serum cholesterol levels, The structure of simvastatin and related compounds is shown in Fig.1. It contains a hexahydronaphthalene ring system, a β-hydroxylactone and dimethylbutyrate structural unit.
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Zuo Yumin, Xu Jie, Ren Sumei. Structural Analysis of Simvastatin[J]. Chem. J. Chinese Universities, 1998, 19(S1): 448.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/448