Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 36.
• Organic Synthesis Chemistry • Previous Articles Next Articles
Daqiang Xu, Kapa Prasad, Oljan Repic, Thomas J. Blacklock
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Abstract: 1,3-Diaryl-4-pyrazoleacetic acids and derivatives exhibit multiple biological activities.1 For example, Lonazolac® is listed in Merck index as an antiinflammatory and analgesic agent. We were interested in this type of compounds for their potential applications in anti-diabetics. One of the leading candidates, SDZ RGU 825,has been shown to enhance whole-body glucose disposal without increasing insulin secretion. Therefore, it was developed for treatment of "non-insulin-dependent diabetes mellitus",the type Ⅱ diabetics.
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Daqiang Xu, Kapa Prasad, Oljan Repic, Thomas J. Blacklock. A General and Facile Synthesis of l,3-Diaryl-4-pyrazoleacetic Acids and Its Application in the Synthesis of SDZ RGU 825[J]. Chem. J. Chinese Universities, 1998, 19(S1): 36.
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