Abstract: The β-trialkylgermanyl propanoic acid、β-triphenylgermanyl propanoic acid and their derivatives exhibit anti-inflaxnmatory and antibacteria activities[1]. And both phosphonic acids and their derivatives have bioactivities, e.g. antibacteria[2]、antitumor[3],etc. But synthesis and bioactivities of organogermanium compounds containing phosphoryl structures have seldom been reported. In order to look for new compounds having potent efficient anticancer and antiinflammatory activities, We designed and synthesized organogermanium compounds containing phosphoryl groups Ⅰ and Ⅱ,and studied the methods of synthesis, as well as structures and properties of the products.