Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 356.
• Organometallic Chemistry • Previous Articles Next Articles
Wang Qingmin, Zeng Xianshun, Cui Tao, Zeng Qiang
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Abstract: During the past two decades, carboxyethylgermanium sesquioxide Ge-132[O3(GeCH2CH2COOH)2] and its derivatives have attracted considerable attention because these organogermanium sesquioxides exhibited anticancer activities[1,2]. In 1993, Kurono et al. have synthesized phosphonoethylgermanium sesquioxide[O3/2GeCH2CH2PO(OH)2], which possesses higher antitumor activity than Ge-132[3]. Encouraged by these promising results, we developed the idea that the incorporation of a germanium residue into α-aminophosphonic acids and their derivatives, which have antibacteria and antitumor activities[4,5], would enhance their antitumor activities to a significant degree, while their toxicity would be reduced at the same time. Therefore, we designed and synthesized a series of novel organogermanium sesquioxides containing α-aminophosphonate groups by the hydrolysis of O,O-diphenyl N-trichlorogermyl propiono-α-aminophosphonates.
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Wang Qingmin, Zeng Xianshun, Cui Tao, Zeng Qiang. Synthesis of Novel Organogermanium Sesquioxides and Reactivities of 3-(Trichlorogermyl)propanoic Acid[J]. Chem. J. Chinese Universities, 1998, 19(S1): 356.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/356