Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 355.
• Organometallic Chemistry • Previous Articles Next Articles
Liu Hua, Chen Xue-Ren, Wang Ji-Tao, Xie Qing-Lan, Li Jing
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Abstract: The drug molecule is called as silα-drug if one carbon atom is substituted by silicon atom in the organic-drugs. Generally, drugs of this kind have low toxicity and pro-long efficiency. People have designed many methods in order to decrease the toxicity of organotin compounds and organosilicon has proved to be effective. Torque[1] is a new acaricide made by Shell company in America, its structure is[(PhMe2CCH2)3SnI2O. R. Tacke[2] from Germany synthesized the compounds (PhMe2SiCH2)3SnX[X=HO, (PhMe2SiCH2)3SnO] and tested the acaricidal activity of[(PhMe2EICH2)3Sn]2O (EI=C, Si) in 1986. He proved that the silyl-derivatives of Torque were highly effective acaricides.
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Liu Hua, Chen Xue-Ren, Wang Ji-Tao, Xie Qing-Lan, Li Jing. Synthese,Structure and Acaricidal Activity of Triorganyl Chlorostannanes/Containing Silicon[J]. Chem. J. Chinese Universities, 1998, 19(S1): 355.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/355