Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (S1): 162.
• Organic Synthesis Chemistry • Previous Articles Next Articles
Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI
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Abstract: Some Ligularia species have long used as folk remedies due to their antibiotic, antiphlogistic and antitumor activities.1 Compound 1,2 a novel coniferyl alcohol, was isolated from ligularia duciformis(Compoitae). The geometrical structure of 1,determined by spectroscopic techniques, was corresponded to 4-o-(6,-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl alcohol. But its absolute configuration at C-6,has not yet been determined. Herein, we report the total synthesis of (6'S)-(-)-1 from Geraniol 2 through 9 steps (Scheme 1).
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Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI. First Total Synthesis of (-)-4-O-(6'-Hydroxy-7'(9')-Dehydro-6',7,-Dihydrogeranyl)-Coniferyl Alcohol[J]. Chem. J. Chinese Universities, 1998, 19(S1): 162.
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http://www.cjcu.jlu.edu.cn/EN/Y1998/V19/IS1/162