Abstract: The naturally occurring dihydroagarofuran compounds have been demonstrated to show some important bioactive activities, such as insect antifeedant, antitumor activities.¹ Synthetic research of this kind of compounds have been attracting the increasing interest of organic chemists. Because a total synthesis of polyol skeleton involved too many steps,² our synthetic efforts are focusing on search for a short and efficient approach and thus, we begin with readily available α-(-)-santonin(1). The creative key steps include generation of C₅-OH, the stereochemical reversion at C-7 and the cyclization of tetrahydrofuran. A successful approach is shown in the following scheme.