Synthesis and Biological Activities of Novel 2-Amino-5-benzylidene-4H-imidazolin-4-one Derivatives

Abstract

Abstract: The carbodiimide 2, which was obtained from aza Wittig reaction of vinyliminophosphorane with aromatic isocyanate, reacted with nucleophiles to give ten novel 2-amino-5-benzylidene 4H-imidazolin-4-one derivatives. The reactivity of carbodiimide 2 towards various nucleophiles was studied and a gualidene like intermediate 3i was isolated from the reaction mixture.Preliminary evaluation of the biological activities of compound 4 was made.

Key words: Imidazolinone, Carbodiimide, Aza-Wittig reaction, Biological activity

CLC Number:

O622
O623.59

TrendMD:

DING Ming-Wu, TU Hai-Yang, LIU Zhao-Jie, ZHUANG Nong-Bo . Synthesis and Biological Activities of Novel 2-Amino-5-benzylidene-4H-imidazolin-4-one Derivatives[J]. Chem. J. Chinese Universities, 1998, 19(6): 895.

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Synthesis and Biological Activities of Novel 2-Amino-5-benzylidene-4H-imidazolin-4-one Derivatives

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