Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (12): 1950.

• Articles • Previous Articles     Next Articles

Comparative Molecular Field Analysis of Triazolopyrimidine Sulfonaniline Herbicides

REN Tian-Rui1, CHEN Hong-Ming1, XIE Gui-Rong1, ZHOU Jia-Ju1, CHEN Fu-Heng2   

  1. 1. Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing, 100080;
    2. Department of Applied Chemistry, China Agricultural University, Beijing, 100094
  • Received:1997-08-20 Online:1998-12-24 Published:1998-12-24

Abstract: Triazolopyrimidine herbicides are a new kind of high efficiency ones with acetolactate synthase(ALS) as target. Comparative molecular field analysis(CoMFA) was applied to study the action mode of triazolopyrimidine herbcides on ALS. The QSARresults give the rational reasons to infer a possible binding mode between the inhibitors and ALS, and help to design new inhibitors

Key words: Triazolopyrimidine, Herbicide, Acetolactate synthase, CoMFA

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