Studies on D-Galactose-containing DTPA Bisamide Gadolinium Complexes as Liver-targeting MRI Contrast Agents

Abstract

Abstract: New lactose-or D-galactose-containing diethylenetriaminepentaacetic acidbisamide ligands and their gadolinium complexes were synthesized by the reaction of bis(N-hydroxysuccinimide ester)of diethylenetriaminepentaacetic acid with amino-containing lac-tose or D-galactose derivatives.Chemical structures of ligands and Gd complexes were char-acterized.In vitro spin-lattice relaxivity and acute toxicity in mice of the complexes havebeen preliminarily investigated.Magnetic Resonance lmaging for rabbit shows that the con-trast agent bearing galactose could be targeted to the liver.

Key words: MRI contrast agents, D-Galactopyranosyl group, Relaxivity, Acute toxicity, Liver-targeting

CLC Number:

O622.5

TrendMD:

FU Yan-Jun, ZHUO Ren-Xi. Studies on D-Galactose-containing DTPA Bisamide Gadolinium Complexes as Liver-targeting MRI Contrast Agents[J]. Chem. J. Chinese Universities, 1997, 18(7): 1072.

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Studies on D-Galactose-containing DTPA Bisamide Gadolinium Complexes as Liver-targeting MRI Contrast Agents

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