The Synthesis and Biological Activity of 1-Aryl-4-substituted Pyrazoloyl Thiosemicarbazides and Related Heterocyclic Compounds

Abstract

Abstract: Aseries of new acylthiosemicarbazide derivatives (Ⅲ) were synthesized by addition reaction of 1-phenyl-3-methyl-5-chloro-4-pyrazoloyl isthiocyanate (Ⅰ) with aroyl hydrazines (Ⅱ), which were cyclized under an acidic condition to obtain 2-substituted pyrazoloyl amino-5-aryl-1, 3, 4-thiadiazoles (Ⅳ).The preliminary biological tests indicate thatsome compounds of Ⅲ and Ⅳ show a good herbicidal activity.

Key words: 1-Phenyl-3-methyl-5-chloro-4-pyrazoloyl isothiocyanate, Aroyl hydrazine, Acyl thiosemicarbazide, 1,3,4-Thiadiazole, Herbicidal activity

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JIN Gui-Yu, HOU Zhen, ZHAO Guo-Feng, CAO Chun-Yang, LI Yu-Chang. The Synthesis and Biological Activity of 1-Aryl-4-substituted Pyrazoloyl Thiosemicarbazides and Related Heterocyclic Compounds[J]. Chem. J. Chinese Universities, 1997, 18(3): 409.

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The Synthesis and Biological Activity of 1-Aryl-4-substituted Pyrazoloyl Thiosemicarbazides and Related Heterocyclic Compounds

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