CJCU

Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (10): 1648.

• Articles • Previous Articles     Next Articles

The Cleavage of Trimethylsilyl Ether

WANG En-Si1, SHEN Jia-Cong1, Henry N. C. WONG2   

  1. 1. Department of Molecular Biology, Jilin University, Changchun, 130023;
    2. Dept. of Chem., The Chinese University of Hong Kong, Hong Kong
  • Received:1996-10-29 Online:1997-10-24 Published:1997-10-24

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Abstract: Trimethylsilyl ether of tertiary alcohol can be cleaved by using tetra-n-butylan-monium fluoride (TBAF), acidic hydrolysis, basic alcoholysis and and BF3-Et2O. The resultsshow that BF3-Et2O is a highly selective method, which has not been reported so far.

Key words: Protective group, Trimethylsilyl ether, Deprotecting

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