Synthesis and DNA-binding Studies of Ruthenium Mixed-polypyridyl Complexes

Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (7): 1010.

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Synthesis and DNA-binding Studies of Ruthenium Mixed-polypyridyl Complexes

WU Jian-Zhong, WANG Lei, YANG Guang, ZENG Tian-Xian, JI Liang-Nian

1. Department of Chemistry, Zhongshan University, Guangzhou 510275;
2. State Key Laboratory for OSSO, Lanzhou Institute of Chemical Physics, Chineses Academy of Sciences, Lanzhou

Received:1995-07-17 Online:1996-07-24 Published:1996-07-24

Abstract

Abstract: Two new ligands,imidazo[f],10-phenanthroline(IP)and 2-phenylimidazo[f]1,10-phenanthroline(PIP),and four new complexes,[Ru (bpy)₂(IP)]²⁺(b₂IP),[Ru (bpy)₂(PIP)]²⁺(b₂PIP),[Ru(phen)₂(IP)]²⁺(p2IP)and[Ru(phen)₂(PIP)]²⁺(p₂PIP)were synthesized and characterized.The binding of the complexes to calf thymus DNAwas investigated by using electronic absorption,steady-state luminescence and circular dichroism spectra.The order of total binding affinities was found to be b₂IP<b₂PIP≤p₂IP<p₂PIP,consistent with the order of the ligands'planarities,π-electron extension and hydrophobicities,bpy《phen

Key words: Ruthenium(Ⅱ), Imidazo[f], 1,10-phenanthroline, 2-phenylimidazo[f]1,10-phenanthroline, Calf thymus DNA

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WU Jian-Zhong, WANG Lei, YANG Guang, ZENG Tian-Xian, JI Liang-Nian. Synthesis and DNA-binding Studies of Ruthenium Mixed-polypyridyl Complexes[J]. Chem. J. Chinese Universities, 1996, 17(7): 1010.

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Synthesis and DNA-binding Studies of Ruthenium Mixed-polypyridyl Complexes

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