Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (4): 571.
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HUANG Run-Qiu, LI Hui-Ying, MA Jun-An, QIU De-Wen
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Abstract: The O-(4quinazplinyl)oxime ethers compounds were synthesized by the reactionof 4-chloro quinazoline and substituted aryl oximes under a base.Their structures were confirmed by means of elementary analysis.IR,1H NMRand MS.The preliminary bioassayshows that some compounds have higher antiviral activity against TMV than 1,3,5-triazine-hexahvdro-2,4-dione(DHT);CompoundsⅠ6 and Ⅰ11, at~0.3 mmol/L, results in 60%and 65%inhibition of TMVin nicotiana tabacum leaves respectively, compared to 45% usingDHT,at 0.9mmol/L.
Key words: Quinazoline, Oxime-ether, Antiviral activity
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HUANG Run-Qiu, LI Hui-Ying, MA Jun-An, QIU De-Wen. Synthesis of O-(4-Quinazolinyl)oxime Ethers and Their Antiviral Activity[J]. Chem. J. Chinese Universities, 1996, 17(4): 571.
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http://www.cjcu.jlu.edu.cn/EN/Y1996/V17/I4/571