Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (3): 409.
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WANG Hong, JI Hong, ZHANG Ruo-Heng, XU Xiao-Jie, TANG You-Qi
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Abstract: In order to study the racemization in thioester condensation,a model coupling reaction between Boc-Ala-Ala-SCH2CH2CO-GlyOBzl and GlyOBzl·TosOHwas monitored by RP-HPLC.To optimize reaction conditions,the effects of solvents,additives and bases were checked.From the results, we conclude that THFis recommendable as a solvent and when thioester:HOsu:NMMis 1:15:12(molar ratio),there is the least racemization(<2%).
Key words: Thioester condensation reaction, RP-HPLC, Racemization ratio
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WANG Hong, JI Hong, ZHANG Ruo-Heng, XU Xiao-Jie, TANG You-Qi. Studies on Racemization in Thioester Condensation[J]. Chem. J. Chinese Universities, 1996, 17(3): 409.
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http://www.cjcu.jlu.edu.cn/EN/Y1996/V17/I3/409