Studies on Action Receptor to Natural Product Epibatidine

Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (11): 1742.

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Studies on Action Receptor to Natural Product Epibatidine

XU Jian-Ping¹, HE Dong¹, WANG Zhi-Zhong², SHEN Jia-Cong¹, GAO Lian-Xun³, SONG Ya-Ru⁴

1. Department of Chemistry, Jilin University, Changchun, 130023;
2. Institute of Theoretical Chemistry, Jilin University, Changchun, 130023;
3. Changchun Institute of Applied Chemistry;
4. Dept. of Chem., Bejing Normal University, Beijing

Received:1995-11-29 Online:1996-11-24 Published:1996-11-24

Abstract

Abstract: According to the theoretical calculation of epibatidine and nicotine by using AM1 method,we made a good explaination for the phenomenon that the analgetic action of epibatidine doesn't be reversed by naloxone as usual analgetics for the first time,and this result supports the results of Daly's experiment.In addition,as epibatidine and micotine have many similarities such as structure,activity and other qualities,so we believe that they also have the same action receptor-nicotine receptor.

Key words: Epibatidine, Nicotine, Action receptor, AM1

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XU Jian-Ping, HE Dong, WANG Zhi-Zhong, SHEN Jia-Cong, GAO Lian-Xun, SONG Ya-Ru. Studies on Action Receptor to Natural Product Epibatidine[J]. Chem. J. Chinese Universities, 1996, 17(11): 1742.

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Studies on Action Receptor to Natural Product Epibatidine

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