Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (1): 85.

• Articles • Previous Articles     Next Articles

Total Synthesis of 3,7,11-Trimethyl-10-Oxo-Dodecanoic Acid

LIYing, HUANG Chu-Sheng, LI Wei-Dong, LI Yu-Lin   

  1. State Key Iarboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Ianzhou 730000
  • Received:1995-01-07 Online:1996-01-24 Published:1996-01-24

Abstract: The title compound,3,7,11-trimethyl-10-oxo-dodecanoic acid,a new sesquiter-pene isolated from Caulerpa recemosa was synthesized through eight steps starting fromgeraniol in an overall yield of 18.5%,The key step was the regioselective alkylation ofmethyl isopropyl ketone.

Key words: Sesquiterpene, 3,7,11-Trimethyl-10-oxo-dodecanoic acid, Total synthesis, Re-gioselective alkylation

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