Studies on Solid State Reaction of 1-Phenyl-3-methyl-5-Pyrazolone with Dicarbonyl Compounds

Abstract

Abstract: The solid state reactions of benzil,p-dimethylaminobenzil,4,4′-dibromobenzil,p-dimethylaminobenzoin and o-phthalimide with 1-phenyl-3-methyl-5-pyrazolone were re-ported. This thermal reaction was carried out at 120℃ for 0.5hand gave one of the 1:1condensation isomers in a higher selectivity. The structures of seven new products wereidentified by IR,¹HNMR, MSand elementary analysis, and the configuration of the prod-uct 1-phenyl-3-methyl-4-benzoylphenylmethylene-5-pyrazolone 1 was determined by X-raydiffraction analysis. In the molecule of compound 1, there is four plans rather than coplanar.Benzoyl group and COgroup of five membered ring are in cis-positions, the interaction ofoxygen atoms leads to noncoplanar.

Key words: Solid state reaction, 1-phenyl-3-methyl-5-pyrazolone, Dicarbonyl compound

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DU Da-Ming, WANG Yong-Mei, MENG Shuang-Ming, LIANG Shu-Sen, MENG Ji-Ben, ZHOU Xiu-Zhong. Studies on Solid State Reaction of 1-Phenyl-3-methyl-5-Pyrazolone with Dicarbonyl Compounds[J]. Chem. J. Chinese Universities, 1996, 17(1): 81.

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Studies on Solid State Reaction of 1-Phenyl-3-methyl-5-Pyrazolone with Dicarbonyl Compounds

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