Studies on the Structure and Properties of N1′-Methyl Indirubin Monooxime

Abstract

Abstract: In this paper the synthesis,crystalline structure and properties of N_1′-methyl in-dirubin monooxime(MIM)are reported.The antileukemic activity was determined by themethylene blue method in vitro and proved to be better than that of indirubin clearly. Its wa-ter-solubility and fat-solubility power are better than those of indirubin, Crystalline structure of MIMwas determined by X-ray diffraction method.The crystalline composition C₁₇H₁₃N₃O₂,M_r=291.21.The crystal is monoclinic,space group P2₁/c, with a=1.5226(4) nm,b=0. 6524(3)nm,c=1.6562(5) nm:β=103.69(4)°,Z=4.The final deviation factor R=0.043.The molecule is approximately planar.

Key words: N_1′-Metliyl indirtibin monooxime, Antileukemia/activity, Molecular structure, Crystalline structure, Structtire-activity relationship

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TIAN Fa-An, GONG Kao-Cai, LI Chun-Min. Studies on the Structure and Properties of N_1′-Methyl Indirubin Monooxime[J]. Chem. J. Chinese Universities, 1996, 17(1): 69.

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Studies on the Structure and Properties of N_1′-Methyl Indirubin Monooxime

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