Synthesis and Proton Relaxivity of Gd-EDDS and Gd-EDDS and Gd-THEC

Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (1): 24.

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Synthesis and Proton Relaxivity of Gd-EDDS and Gd-EDDS and Gd-THEC

LU Zheng-Rong¹, ZHUO Ren-Xi¹, YIN Chao¹, ZHOU Jian-Wei²

1. Department of Chemistry, Wuhan University, Wuhan 430072;
2. Wuhan Institute of Physics, Chinese Academy of Sciences

Received:1995-01-11 Online:1996-01-24 Published:1996-01-24

Abstract

Abstract: Two amino acid derivative ligands,ethylenediamine-N,N′-disuccinic acid(EDDS)and N,N,N′,N′-tetrahydroxyethylcystine(THEC),were synthesized from the reaction ofL-aspartic acid with 1,2-dibromoethane and L-cystine with chloroethanol respectively. Theirparamagnetic gadolinium(Ⅲ) complexes were prepared by the reaction of the ligands with Gd₂O₃ and Gd(OAc)₃ respectively. The ligands and their Gd(Ⅲ) complexes were character-ized by IR,1HNMRspectroscopy and elemental analysis. The proton relaxivity of the com-plexes was investigated, and the R₁ values of Gd(Ⅲ)-EDDSand Gd(Ⅲ)-THECare 10.33and 6.62 mmol^-1·L·s^-1,respectively.

Key words: Aspartic acid derivative, Cystine derivative, Gd(Ⅲ)complex, Relaxivity

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LU Zheng-Rong, ZHUO Ren-Xi, YIN Chao, ZHOU Jian-Wei. Synthesis and Proton Relaxivity of Gd-EDDS and Gd-EDDS and Gd-THEC[J]. Chem. J. Chinese Universities, 1996, 17(1): 24.

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Synthesis and Proton Relaxivity of Gd-EDDS and Gd-EDDS and Gd-THEC

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