Abstract: In order to look for novel antitumor drugs and virucides with high activity and low toxicity,a series of the title compounds were synthesized by the addition reaction of N,N-bis( 2-chloroethyl)-O-aryl isothiocyanatido phosphoramidate with aryl amine,and their structures were confirmed by spectroscopic and analytical methods. The relationship between the chemical shifts and structures was revealed. The existence of the intermolecular and intramolecular hydrogen-bondings leads to deshielding and to an increase in the frequency of the NMR signal of the hydrogen-bonded protons. Preliminary bioassays indicate that some of them have good inhibitory effects to the growth of different tumor cells such as BGC,HCT,HL₆₀and BCAP cell lines in human bodies and display a high activity against tobacco mosaic virus(TMV).

Key words: Phosphoramidate, Thioureido, Antivirals, Antitumor agents