Studies on the Syntheses and Biological Activties of trans-Cyclothiophosphorylthioureas

Abstract

Abstract: Thirteen new trans-cyclothiophosphorylthiourea derivatives,R¹R²NC(S) NHR³(R¹=H,alkyl;R²=alkyl, substituted plienyl;R³=4-phenyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosplioranyl),were synthesized by the addition reaction of frans-2-isothiocyano-4-plienyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosphorinane to various amines respectively and their structure were confirmed by means of elemental analysis,¹HNMR and IR. The biological activities of all new compounds were tedsted preliminarily and the results indicate that some compounds showed fungicidal activity and plant-growth reguiarity activity. In addition,the stereochemistry of the reaction between 2-chloro-4-phenyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosphorinane and potassium thiocyanate was reported for the first time.

Key words: 1,3,2-Dioxaphosphorinane, Thiourea, Stereochemistry, Diastereoisomer, Biological activity

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SHAO Rui-Lian, YANG Guang-Fu, MIAO Wei-Shi, LI Guang-Ren . Studies on the Syntheses and Biological Activties of trans-Cyclothiophosphorylthioureas[J]. Chem. J. Chinese Universities, 1995, 16(3): 391.

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Studies on the Syntheses and Biological Activties of trans-Cyclothiophosphorylthioureas

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