CJCU

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (10): 1629.

• Articles • Previous Articles     Next Articles

Studies on Water-Soluble Metalloporphyrins as Tumor Targeting Magnetic Resonance Imaging Contrast Agents

LUO Yi1, MEI Er-Wen2, ZHUO Ren-Xi3   

  1. 1. Department of Chemistry, Peking University, Beijing, 100871;
    2. Department of Analytic Science, Department of Chemistry, Wuhan University, Wuhan, 430072;
    3. Department of Chemistry, Wuhan University, Wuhan, 430072
  • Received:1994-10-12 Revised:1995-05-21 Online:1995-10-24 Published:1995-10-24

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Abstract: The development of nuclear magnetic resonance imaging technique has provided a noninvasive method for in vivo research in biological systems.Compounds which affect the relaxation time could provide additional contrast for NMR images and are potentially useful in a clinical setting.Synthesis of targeting MRI contrast agents for specific tissue and organs is the most attractive field in the recent MRI studies.In this work,four water-soluble metalloporphyrins,Cu(Ⅱ)-TSPP,Mn(Ⅱ)-TSPP.Cu(Ⅱ)-TMAP,Mn(Ⅲ)-TMAP Were synthesized and their structures were confirmed by UV,IR,1HNMR and elemental analysis.Targeting to S180tumor cells of these water-soluble porphyrins was studied in vitro by microscope fluorescence-Hadamard transform three-dimensional image analysis.The spin-lattice relaxivity(R1)of Mn(Ⅱ)-porphyrin chelate is 1.5-2 times larger than that of Gd-DTPA.

Key words: Water-soluble metalloporphyrin, Tumor targeting, Microscope fluorescence-Hadamard transform three-dimensional image analysis, Spin-lattice relaxivity

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