Studies on Condensed Heterocyclic Compounds (XVI)─Synthesis of 1-Aryl-1, 2, 3-triazolo[4,5-e] pyrimidineone and Piperidine or Azacyclooctane [1,2-b] pyrimidineone Compounds

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (12): 1787.

• Articles • Previous Articles Next Articles

Studies on Condensed Heterocyclic Compounds (XVI)─Synthesis of 1-Aryl-1, 2, 3-triazolo[4,5-e] pyrimidineone and Piperidine or Azacyclooctane [1,2-b] pyrimidineone Compounds

ZHANG Zi-Yi¹, LIU Ying¹, CHEN Mao-Qi², YANG Shi-Yan²

1. Department of Chemistry, Lanzhou University, National Laboratory of Applied Organic Chemistry, Lanzhou, 730000;
2. Lanzhou Institute of Chemical Physics, Academia Sinica, Lanzhou

Received:1993-12-14 Revised:1994-06-20 Online:1994-12-24 Published:1994-12-24

Abstract

Abstract: For the purpose of studying the relationship between molecular structures and biological activies of condensed heterocyclic compounds as a part of our recent progress, a series of new heterocyclic derivatives, 5H-1-aryl-1, 2, 3-triazolo[4, 5-e] pyrimidine-4-one(2a-c), 5-N-methyl-1-aryl-1, 2, 3-triazolo[4, 5-e]pyrimidine-4-one(3a-c), 1-aryl-4-ethoxycarbonyl-5-uramine-1, 2, 3-triazole(4(a, b)), 5H-1-aryl-1, 2, 3-triazolo[4, 5-e] pyrimidine-4, 6-dione( 5(a, b)), 1-aryl-1, 2, 3-triazolo[4, 5-e]piperidine[1, 2-b]pyrimidine-4-one(6a)and 1-aryl-1, 2, 3-triazo-lo[4, 5-e] azacyclooctane[1, 2-b] pyrimidine-4-one (7a), were prepared by treating l-aryl-4-ethyloxycarbonyl-5-amino-1, 2, 3-triazoles 1 with formamide, chlorosulphonyl isocyanate, lactin respectively. The structures of all compounds were confirmed by elemental analysis, IR, ¹H NMRand MS. Their antibacterial activities against B. Subtilis, E. coli, E. aerogenes; S. aureus were observed.

Key words: Condensed heterocyclic compound, 1-Aryl-1,2,3-triazolo[4,5-e] pyrimidineone, 1-Aryl-1,3-triazolo[4,5-e]piperidine[1,2-b] pyrimidine-4-one, 1,3-Triazolo[4,5-e]azacyclooctane[1,2-b]pyrimidine-4-one, Biological activity

TrendMD:

ZHANG Zi-Yi, LIU Ying, CHEN Mao-Qi, YANG Shi-Yan. Studies on Condensed Heterocyclic Compounds (XVI)─Synthesis of 1-Aryl-1, 2, 3-triazolo[4,5-e] pyrimidineone and Piperidine or Azacyclooctane [1,2-b] pyrimidineone Compounds[J]. Chem. J. Chinese Universities, 1994, 15(12): 1787.

[1]	WEI Simin,WANG Yinghui,TANG Zhishu,SU Rui,HU Jinhang,GUO Hui,LI Chen,JIANG Jintao,SONG Zhongxing. Novel Biosynthesis Method of Silver Nanoparticle by UV Radiation of Cornus Officinalis Aqueous Extract and Biological Activities ^† [J]. Chem. J. Chinese Universities, 2020, 41(6): 1391.
[2]	SHI Yujun, FANG Yuan, LI Yang, CHEN Jia, LI Gang, WANG Qingmin, DAI Hong. Synthesis and Biological Activities of Novel Cyanoacrylate Derivatives Carrying 5-Arylisoxazole Group^† [J]. Chem. J. Chinese Universities, 2017, 38(3): 421.
[3]	ZHANG Lingzhi, JIANG Minrui, WEI Ping, ZHU Qihua, GONG Guoqing, BIAN Xueguo, XU Yungen. Synthesis, Metabolic Stability and Biological Activity in vivo of Lorcaserin Derivatives^† [J]. Chem. J. Chinese Universities, 2017, 38(10): 1778.
[4]	ZHANG Yan, WANG Baolei, ZHAN Yizhou, ZHANG Liyuan, LI Yonghong, LI Zhengming. Synthesis and Biological Activities of Novel 5-(Pyridine-3-yl)-1,2,4-triazole Mannich Bases and Bis-Mannich Bases Containing Piperazine Moiety^† [J]. Chem. J. Chinese Universities, 2016, 37(6): 1100.
[5]	XU Gaofei, LIU Yanhong, YANG Xinling, WANG Daoquan, YUAN Dekai. Synthesis and Biological Activity of Novel Dicyano-containning Cyclopropane-1-carboxamides^† [J]. Chem. J. Chinese Universities, 2016, 37(3): 486.
[6]	QIN Yaoguo, ZHANG Jingpeng, SONG Dunlun, DUAN Hongxia, LING Yun, JIANG Biaobiao, WANG Di, YANG Xinling. Design, Synthesis and Biological Activity of Novel Aphid Alarm Pheromone Analogues Containing Isonicotinic Acid^† [J]. Chem. J. Chinese Universities, 2016, 37(11): 1977.
[7]	WANG Zijian, SUN Xiaohong, LIU Yuanfa, CHEN Bang, SHEN Shengqiang, JIN Ruyi, MA Haixia. Synthesis and Biological Activities of 1,2,4-Triazole Schiff Bases Containing Pyrazole Rings^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1315.
[8]	LI Xu, JIANG Jianhong, HAN Buxing, GU Huiwen, XIE Zhaofeng, CHEN Lan, XIAO Shengxiong, LI Chuanhua, LI Aitao, LI Xia, YAO Feihong, WANG Qun, LI Qiangguo. Synthesis and Biological Activities of o-Vanillin-histidine Schiff-base and Its Lanthanum Complex^† [J]. Chem. J. Chinese Universities, 2015, 36(5): 856.
[9]	SHEN Shengqiang, SUN Xiaohong, LIU Yuanfa, CHEN Bang, JIN Ruyi, MA Haixia. Synthesis and Biological Activity of 1,3,4-Oxadiazole Mannich Bases Containing Pyrimidine Rings^† [J]. Chem. J. Chinese Universities, 2014, 35(7): 1427.
[10]	LIU Shaohua, LING Yun, LI Hongyue, XU Dan, YANG Xinling. Design, Synthesis and Biological Activity of Novel Substituted Phenyl Oxazol Based Compounds^† [J]. Chem. J. Chinese Universities, 2014, 35(2): 281.
[11]	WANG Xin-Zhong, LIU Jian-Guo, TANG Yu-Feng, WANG Yu, ZHANG Pei-Biao, CHEN Xue-Si. Preparation of Controlled-release PLA Microspheres Loading Methylsulfonylmethane and Its Biological Activity [J]. Chem. J. Chinese Universities, 2013, 34(4): 984.
[12]	JI Xu, BIAN Liu-Jiao. Bioactive Change and Structural Change of Bacillus Amyloliquefaciens α-Amylases Induced by Ca²⁺ [J]. Chem. J. Chinese Universities, 2013, 34(11): 2517.
[13]	CHEN Zhe, KWONG Anna Ka-Yee, YANG Zhen-Jun, ZHANG Liang-Ren, LEE Hon Cheung, ZHANG Li-He. Synthesis and Biological Evaluation of Nicotinamide Adenine Dinucleotides Analogues as Inhibitors of CD38 [J]. Chem. J. Chinese Universities, 2012, 33(06): 1226.
[14]	XU Jun-Ying, DONG Wei-Li, XIONG Li-Xia, LI Zheng-Ming. Design, Synthesis and Biological Activities of Amides(Sulfonamides) Containing N-Pyridylpyrazole [J]. Chem. J. Chinese Universities, 2012, 33(02): 298.
[15]	LI Chen, YANG Zheng, SHE Meng-Yao, YIN Wen-Ting, LI Jian-Li*, ZHAO Gui-Fang, SHI Zhen. Recent Progress in Superoxide Dismutase Mimics [J]. Chem. J. Chinese Universities, 2011, 32(9): 2046.

Studies on Condensed Heterocyclic Compounds (XVI)─Synthesis of 1-Aryl-1, 2, 3-triazolo[4,5-e] pyrimidineone and Piperidine or Azacyclooctane [1,2-b] pyrimidineone Compounds

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments