Synthesis of N-Isopropyl-O-aryl-O'-galatopyranosyl thiophosphoramidates and Their Biological Activity

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (11): 1643.

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Synthesis of N-Isopropyl-O-aryl-O'-galatopyranosyl thiophosphoramidates and Their Biological Activity

CHEN Ru-Yu, CHEN Xiao-Ru

Institute of Elemento-Organic Chemistry, Nankai university, Tianjin, 300071

Received:1993-12-02 Revised:1994-04-04 Online:1994-11-24 Published:1994-11-24

Abstract

Abstract: The synthesis of novel N-isopropyl-O-aryl-O'-galactopyranosyl thiophosphoramidates was reported, and the conditions of the reactions were discussed.Apure isomer of N-isopropyl-O-(p-chlorophenyl)-O'-galactopyranosyl thiophosphoramidate 3_d, 3d' , was obtained by recrystallization from diethyl ether-petroleum ether. The result of X-ray diffraction analysis showed that the configuration of the chiral phosphorus atom of 3_d' was of R-form.The herbicidal and antidisease activities of the title compounds were tested.

Key words: Thiophosphoramidate, Galactopyranosyl, Herbicidal activity, Antidisease activity

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CHEN Ru-Yu, CHEN Xiao-Ru. Synthesis of N-Isopropyl-O-aryl-O'-galatopyranosyl thiophosphoramidates and Their Biological Activity[J]. Chem. J. Chinese Universities, 1994, 15(11): 1643.

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Synthesis of N-Isopropyl-O-aryl-O'-galatopyranosyl thiophosphoramidates and Their Biological Activity

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