Rapid Detection of Carcinogenicity of Metal Ions by Using O2 Electrode with Bacillus Subtilis Rec-assay Strains

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (11): 1620.

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Rapid Detection of Carcinogenicity of Metal Ions by Using O₂ Electrode with Bacillus Subtilis Rec-assay Strains

LI Hui¹, Diliber¹, DENG Jia-Qi¹, CHEN Zhong-Fu²

1. Chemistry Department, Genetic Research Institute, Frudan university, Shang Hai, 200433;
2. Genetic Research Institute, Frudan university, Shang Hai, 200433

Received:1993-11-29 Revised:1994-04-15 Online:1994-11-24 Published:1994-11-24

Abstract

Abstract: Asimplified, efficient method has been constructed by combining O₂ electrode andBacillus subtilis rec-assay strains to detect genetoxicity of various metal ions. The resultsshow that this method can be used to detect genotoxic metal compounds with a high sensitivity and fidelity, and the carcinogenicity of Cr⁶⁺, Co²⁺, Cd²⁺, Mn²⁺ ions are confirmed. Themanipulations are very simple, and reproducible responses was gained within half an hour.So this method can be applied to the screening of environmental metal compounds.

Key words: Genetoxicity, Metal ions, Bacillus subtilis

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LI Hui, Diliber, DENG Jia-Qi, CHEN Zhong-Fu. Rapid Detection of Carcinogenicity of Metal Ions by Using O₂ Electrode with Bacillus Subtilis Rec-assay Strains[J]. Chem. J. Chinese Universities, 1994, 15(11): 1620.

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Rapid Detection of Carcinogenicity of Metal Ions by Using O₂ Electrode with Bacillus Subtilis Rec-assay Strains

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