Solid Phase Synthesis and Biological Activities of α-h-ANF and Its Analogs

Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (10): 1247.

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Solid Phase Synthesis and Biological Activities of α-h-ANF and Its Analogs

ZHANG Ran, WANG Yu-Hong, ZHU Zhi-Hua, GUO Li-Li, XU Jian-Ping, WANG Zong-Mu, LI Wei

Department of Molecular Biology, Jilin University, Changchun, 130023

Received:1991-11-04 Revised:1992-05-24 Online:1992-10-24 Published:1992-10-24

Abstract

Abstract: Based upon a structural working model for ANF's functioning mechanism,two analogs of α-h-ANF were designed.Using Fmoc-AA-Pfp as monomer,α-h-ANFand its analogs cited above were synthesized by a solid phase procedure with a high yield and purity.The biological activity study of rabbit aorta shows that one of the analogs is twice and another about one and a half times more active than α-h-ANF itself.

Key words: α-h-ANF analogs, Solid phase polypeptide synthesis, Computer-auxiliary molecular design, Biological activity

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ZHANG Ran, WANG Yu-Hong, ZHU Zhi-Hua, GUO Li-Li, XU Jian-Ping, WANG Zong-Mu, LI Wei. Solid Phase Synthesis and Biological Activities of α-h-ANF and Its Analogs[J]. Chem. J. Chinese Universities, 1992, 13(10): 1247.

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Solid Phase Synthesis and Biological Activities of α-h-ANF and Its Analogs

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