Rapid Alkaline Degradation Determination of Trace Chlorotetracycline by Flow Injection Fluorimetry

Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (10): 1233.

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Rapid Alkaline Degradation Determination of Trace Chlorotetracycline by Flow Injection Fluorimetry

ZHAO Yi-Bing, YU Zhi-Xiong, GUO Xiang-Qun, XU Jin-Gou, CHEN Guo-Zhen

Department of Chemistry, Xiamen University, Xiamen, 361005

Received:1991-10-19 Revised:1992-06-22 Online:1992-10-24 Published:1992-10-24

Abstract

Abstract: The present paper covers a new flow injection fluorimetric method for the determination of trace chlorotetracycline.Chlorotetracycline reacts rapidly with 0.25 mol/L NaOHin a reaction tube and produces strong fluorescent species detected by fluorimetry in a flow cell.The fluorescence intensity of the product is proportional to the concentration of chlorotetracycline over the range of 10^-8～10^-5 mol/L.Coexisting tetracycline and anhydrochlorotetracycline do not interfere with the determination of chlorotetracycline.This method can be used not only for the quality detection of chlorotetracycline medicine but also for the determination of chlorotetracycline in tetracyline medicine.The determination of chlorotetracyciine in urine and serum is successful with satisfactory recoveries.

Key words: Flow injection analysis, Alkaline degradation, Fluorimetry, Chlorotetracycline

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ZHAO Yi-Bing, YU Zhi-Xiong, GUO Xiang-Qun, XU Jin-Gou, CHEN Guo-Zhen . Rapid Alkaline Degradation Determination of Trace Chlorotetracycline by Flow Injection Fluorimetry[J]. Chem. J. Chinese Universities, 1992, 13(10): 1233.

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Rapid Alkaline Degradation Determination of Trace Chlorotetracycline by Flow Injection Fluorimetry

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