Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (1): 70.
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CAI Song-chuan, ZHAO Tao-nan, SUN De-hua, ZHANG Dao-xin, BAO Yan-chu
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Abstract: N-oxidation of 5-alkyl-2, 3-dimethylpyrazines with 30% H2O2-AcOHusually gives 1-N-oxides, 4-N-oxides and 1,4-N-dioxides.When the molar ratio of pyrazines/H2O2/AcOHis 1 : 1.2 : 15 at 70℃, the reaction is gives mono-N-oxides with best yields.N-oxidation of ten 5-alkyl-2,3-dimethylpyrazines were carried out under the above conditions, giving thirteen new compounds 5-alkyl-2,3-dimethylpyrazine-mono-N--oxid.es with satisfactory yields (50%~70%).Their structures were confirmed by elemental analysis, IR,1H NMRand MSspectrometry.The structures of 1-N-oxides and 4-N-oxides were determined on the basis of 1H NMRspectral data, since the N-oxide group in substituted pyrazine mono-N-oxides gives the anisotropic effect.Additionally, the structures of eight new 1,4-N-dioxides obtained were confirmed by elemental analysis, IRand 1H NMRspectrometry.
Key words: 5-Alkyl-2,3-dimethyipyrazine, N-Oxidation, 5-Alkyl-2,3-dimethylpyrazine 1-N-oxide
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CAI Song-chuan, ZHAO Tao-nan, SUN De-hua, ZHANG Dao-xin, BAO Yan-chu . Synthesis of 5-Alkyl-2,3-Dimethylpyrazine-mono-N-Oxides[J]. Chem. J. Chinese Universities, 1992, 13(1): 70.
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http://www.cjcu.jlu.edu.cn/EN/Y1992/V13/I1/70